Cellular Senescence: A Translational Perspective

Cellular Senescence: A Translational Perspective

Blog Article

Cellular senescence entails essentially irreversible replicative arrest, apoptosis resistance, and frequently acquisition of a pro-inflammatory, tissue-destructive senescence-associated secretory phenotype (SASP).Senescent cells accumulate in various tissues with aging and at sites of pathogenesis in many chronic diseases and conditions.The SASP can contribute to senescence-related inflammation, metabolic dysregulation, stem cell dysfunction, aging a Half phenotypes, chronic diseases, geriatric syndromes, and loss of resilience.Delaying senescent cell accumulation or reducing senescent cell burden is associated with delay, prevention, or alleviation of multiple senescence-associated conditions.We used a hypothesis-driven approach to discover pro-survival Senescent Cell Anti-apoptotic Pathways (SCAPs) and, Coffee based on these SCAPs, the first senolytic agents, drugs that cause senescent cells to become susceptible to their own pro-apoptotic microenvironment.

Several senolytic agents, which appear to alleviate multiple senescence-related phenotypes in pre-clinical models, are beginning the process of being translated into clinical interventions that could be transformative.